KI-ARv-03

SKU: orb3175279

Description

KI-ARv-03 is a potent and selective ATP-competitive CDK9 inhibitor with an IC50 of 0.15 μM (in the presence of 45 μM ATP), demonstrating over 130-fold selectivity for CDK9 over other CDKs (including CDK1-7). It reduces AR-driven transcription and proliferation in prostate cancer cells and is applicable for research on leukemia, pancreatic cancer, alveolar rhabdomyosarcoma (ARMS), and castration-resistant prostate cancer (CRPC). Additionally, KI-ARv-03 serves as a ligand for target protein for PROTAC and is used in the synthesis of PROTAC KI-CDK9d-32.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2416873-72-6
• MW: 259.36
• Formula: C₁₄H₂₁N₅
• SMILES: N(C=1N2C(N=C(CCC)C1)=CC=N2)[C@H]3C[C@H](N)CC3
• Target: Ligands for Target Protein for PROTAC,CDK,c-Myc

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ligands for Target Protein for PROTAC,CDK,c-Myc