KH-4-43

SKU: orb2283545

Description

KH-4-43 is a potent and selective inhibitor of the CRL4 E3 ubiquitin ligase complex, binding its ROC1-CUL4A core with high affinity (Kd = 83 nM). This small molecule is a valuable research tool for investigating CRL4 function in cancer biology and has demonstrated anticancer activity in cellular assays.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 2813310-07-3
• MW: 422.74
• Formula: C₁₉H₁₀ClF₃N₂O₄
• SMILES: C(F)(F)(F)C1=C(C(=O)C=2C(O1)=C(O)C(O)=CC2)C3=CN(N=C3)C4=CC=C(Cl)C=C4
• Target: E1/E2/E3 Enzyme,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

164603779