KG-FP-003

SKU: orb3210675

Description

KG-FP-003 is a highly effective, selective, and durable TEAD PROTAC degrader featuring degradation concentrations of TEAD1DC50= 6 ± 4 nM, TEAD2DC50= 68 ± 15 nM, TEAD3DC50= 12 ± 5 nM, and TEAD4DC50= 7 ± 5 nM. It facilitates the ubiquitination and degradation of TEAD and exhibits anticancer activity against mesothelioma and ovarian cancer.

Key Properties

• CAS Number: 3066008-42-9
• MW: 1049.64
• Formula: C₅₈H₆₇ClF₂N₆O₈
• SMILES: O=C(NC)C=1C=C2C(=C(F)C1C=3C(Cl)=C(F)C=C4OC(C=5C=CC=CC5)(CNC6CCC(C(=O)N7CCC(CC7)CC8CCN(C(=O)COC9=CC=C(C(=C9)C)N%10C(=O)NC(=O)CC%10)CC8)CC6)CC43)C(O)C(C)C2
• Target: PROTACs,YAP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PROTACs,YAP