KG-548

SKU: orb2813904

Description

KG-548 is a small molecule research compound that functions as a dual inhibitor of ARNT/TACC3 and HIF-1α. It disrupts HIF-2 dimerization and coactivator binding, suppressing lactate production. This inhibitor is a valuable tool for investigating cancer metabolism and tumor hypoxia in both in vitro and in vivo models.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 175205-09-1
• MW: 282.15
• Purity: 99.62% (May vary between batches)
• Formula: C₉H₄F₆N₄
• SMILES: FC(F)(F)C1=CC(=CC(=C1)C(F)(F)F)C2=NN=NN2
• Target: HIF/HIF Prolyl-Hydroxylase,Microtubule Associated,HIF
• Solubility: DMSO:80 mg/mL (283.54 mM)

Bioactivity

• In Vitro:
  KG-548 (50 μM) significantly inhibited lactic acid production. KG-548 (1 mM) significantly interfered with the binding of ARNT to one or both co-activators. KG-548 (0-2 mM, 16 h) decomposed the (320 μM) ARNT PAS-B/TACC3 complex in a dose-dependent manner in vitro and in cell lysates with an IC50 of 25 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KG548

Compound Identifiers

PubChem CID

620220