KF38789

SKU: orb1305787

Description

KF38789 is a selective small molecule inhibitor that targets P-selectin, blocking its interaction with ligands such as PSGL-1. It is a valuable research tool for studying inflammation, thrombosis, and cancer metastasis in both in vitro cell adhesion assays and in vivo disease models.

Key Properties

• CAS Number: 257292-29-8
• MW: 375.44
• Purity: 99.81% (May vary between batches)
• Formula: C₁₉H₂₁NO₅S
• SMILES: COc1ccc(C2CC(=NCCS2)C2C(O)OC(C)=CC2=O)c(OC)c1
• Target: Others
• Solubility: DMSO:11.25 mg/mL (29.96 mM)

Bioactivity

• Target IC50:
  P-selectin-Ig:1.97 microM
• In Vivo:
  KF 38789 significantly reduced mechanical allodynia in the facial carrageenan-injected mice.
• In Vitro:
  KF 38789, inhibited the binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with an IC50 value of 1.97 microM. Cell adhesion to both E-selectin-Ig and L-selectin-Ig were not affected even by 100 microM of KF 38789. Moreover, KF 38789 inhibited P-selectin-induced superoxide production from human polymorphonuclear cells. Intravenously injected KF 38789 significantly inhibited the TG-induced accumulation of leukocytes in the mouse peritoneal cavity (p<0.01).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inflammation, KF 38789, KF38789, KF-38789, Inhibitor, Cell adhesion, P-selectin, P-selectin Inhibitor, PSGL-1

Compound Identifiers

PubChem CID

71433798