KF-52

SKU: orb2945134

Description

KF-52 is a potent small molecule inhibitor of phosphofructokinase-1 (PFK1) with an IC50 of 2.1 µM. It shifts cellular metabolism towards oxidative phosphorylation, as evidenced by an increased OCR/ECAR ratio, making it a useful tool for studying glycolysis and metabolic reprogramming in cancer and other diseases in vitro.

Research Area

Metabolism Research

Key Properties

• MW: 404.382
• Formula: C₂₁H₁₉F₃N₂O₃
• SMILES: C1CN([C@@H](C2=C1C3=CC=CC=C3N2)C(F)(F)F)C(=O)[C@@H]4[C@H]5C[C@@H]([C@@H]4C(=O)O)C=C5
• Target: Phosphatase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172676974