KF-20444

SKU: orb3173665

Description

KF-20444 is an orally active ALK inhibitor with the ability to penetrate the blood-brain barrier. It exhibits potent inhibitory effects on ALK fusion proteins (EML4-ALK) and ALK-resistant mutations, including L1196M, G1202R, and F1174L. KF-20444 effectively suppresses the phosphorylation of ALK in cancer cell lines driven by ALK, thereby inhibiting cancer cell proliferation and inducing apoptosis (apoptosis). In mouse models bearing ALK-positive non-small cell lung cancer or neuroblastoma, it demonstrates antitumor efficacy. KF-20444 is applicable for research into ALK-driven malignancies.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 154015-73-3
• MW: 401.41
• Formula: C₂₅H₁₇F₂NO₂
• SMILES: O=C(O)C=1C=2C=C(F)C=CC2N=C3C=4C=CC(=CC4CCCC31)C=5C=CC=CC5F
• Target: Apoptosis,ALK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,ALK