Ketoprofen

SKU: orb1225637

Description

Ketoprofen is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively.(In Vitro):Ketoprofen inhibits COX in LPS-stimulated monocytes isolated from human blood, with IC50 values of 2 nM (COX-1) and 26 nM (COX-2).Ketoprofen (2.5 mg /mL, 3-24h) decreases the mRNA level of immune factors (TNFα, IL-8, SAA and COX-2) and PTGES in LPS-stimulated bovine mammary epithelial cells.\n(In Vivo):Ketoprofen (Oral administration, 10 mg/kg, three times a week for 10 weeks, HFD-induced obese C57BL/6 mice) decreases in relative body weight (15.41%), the iWAT mass (approximately 41%), and leptin (58.68%) and resistin (12.88%).Ketoprofen (50 mg/kg, LPS-treated dairy cows) lowers the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk induced by LPS.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 22071-15-4
• MW: 254.28
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₄O₃
• SMILES: CC(C1=CC=CC(C(C2=CC=CC=C2)=O)=C1)C(O)=O
• Target: COX
• Solubility: Ethanol: 51 mg/mL (200.56 mM); DMSO: 51 mg/mL (200.56 mM)

Bioactivity

• In Vivo:
  Ketoprofen (Oral administration, 10 mg/kg, three times a week for 10 weeks, HFD-induced obese C57BL/6 mice) decreases in relative body weight (15.41%), the iWAT mass (approximately 41%), and leptin (58.68%) and resistin (12.88%). Ketoprofen (50 mg/kg, LPS-treated dairy cows) lowers the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk induced by LPS. Animal model: HFD-induced obese C57BL/6 mice. Dosage: 10 mg/kg. Administration: Oral administration, three times a week for 10 weeks. Result: Decreased in relative body weight, the iWAT mass, and the level of leptin and resistin. Animal model: LPS (0.2 μg/mL)-treated dairy cows. Dosage: 50 mg/kg. Administration: Injection (Milk samples were taken every 30 min until 6 and 9 h). Result: Lowered the increase of somatic cell count (SCC), serum albumin (SA), IgG and lactate dehydrogenase (LDH) activity in milk.
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• In Vitro:
  Ketoprofen inhibits COX in LPS-stimulated monocytes isolated from human blood, with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). Ketoprofen (2.5 mg /mL, 3-24h) decreases the mRNA level of immune factors (TNFα, IL-8, SAA and COX-2) and PTGES in LPS-stimulated bovine mammary epithelial cells. RT-PCR Cell line: LPS (0.2 μg/mL)-stimulated bovine mammary epithelial cells Concentration: 2.5 mg /mL Incubation time: 3, 6, 24 h. Result: Decreased the mRNA level of TNFα, IL-8, SAA, COX-2 and PTGES.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2-(3-benzoylphenyl)propionic Acid | Ketoprofen | (RS)-Ketoprofen

Quick Database Links

Gene Symbol

COX