Kenpaullone

SKU: orb1226311

Description

Kenpaullone (9-Bromopaullone,NSC-664704) is a potent inhibitor of CDK1/cyclin B with IC50 of 0.4 uM, also inhibited CDK2/cyclin A (IC50=0.68 uM), CDK2/cyclin E (IC50-7.5 uM) and CDK5/p25 (IC50=0.85 uM); shows less effect on other kinases, only c-Src, CK2, ERK1/2 (IC50=15-20 uM) with IC50s less than 30 uM; displays delayed cell cycle progression in treated cells; also is a potent inhibitor of GSK-3β (IC50=23 nM), activates Nanog expression in mouse fibroblasts transduced with a subset of reprogramming factors lacking Klf4, can replace Klf4 in the reprogramming of primary and secondary fibroblasts and NPCs.

Key Properties

• CAS Number: 142273-20-9
• MW: 327.1754
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₁BrN₂O
• SMILES: O=C(NC1=CC=CC=C12)CC3=C2NC4=C3C=C(Br)C=C4
• Target: CDK
• Solubility: DMSO: ≥ 35 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

9-Bromopaullone | NSC-664704

Quick Database Links

Gene Symbol

CDK