Keap1-Nrf2-IN-9

SKU: orb1982795

Description

Keap1-Nrf2-IN-9 is a potent small molecule inhibitor of the Keap1-Nrf2 protein-protein interaction (IC50 = 0.575 µM). It activates the Nrf2 pathway, upregulating antioxidant genes like Hmox1 and Gclc in vitro, and shows no cytotoxicity in ARPE19 cells, making it a valuable research tool for studying oxidative stress and cytoprotection.

Research Area

Cancer Biology, Immunology & Inflammation

Key Properties

• CAS Number: 2769963-24-6
• MW: 670.71
• Formula: C₃₁H₃₀N₂O₁₁S₂
• SMILES: COc1ccc(cc1)S(=O)(=O)N(CC(O)=O)c1ccc(N(CC(O)=O)S(=O)(=O)c2ccc(OC)cc2)c(OCc2ccccc2)c1
• Target: Nrf2,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

139582005