Keap1-Nrf2-IN-23

SKU: orb2695487

Description

Keap1-Nrf2-IN-23 (compound 56) is a potent, orally active small molecule inhibitor of the Keap1-Nrf2 protein-protein interaction, with an IC50 of 16.0 nM and a Kd of 3.07 nM for Keap1. It is a valuable research tool for investigating the Nrf2 pathway in oxidative stress and inflammation models, both in vitro and in vivo.

Research Area

Cancer Biology, Immunology & Inflammation

Key Properties

• CAS Number: 2771115-65-0
• MW: 563.04
• Formula: C₃₀H₃₁ClN₄O₅
• SMILES: O=C(O)CC(C1=CC=2N=NN(C2C(OC)=C1)C)C=3C=CC=C4C3CCN(C(=O)C5=CC=C(OC(C)C)C=C5Cl)C4
• Target: Nrf2

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

163363814