Keap1-Nrf2-IN-15

SKU: orb1944470

Description

Keap1-Nrf2-IN-15 (Compound 24a) is a highly potent small molecule inhibitor that disrupts the Keap1-Nrf2 protein-protein interaction. It demonstrates potent activity in biochemical assays, with IC50 values of 77 nM (FP) and 2.5 nM (TR-FRET). This inhibitor is a valuable research tool for investigating the Nrf2 pathway in oxidative stress and disease models, both in vitro and in vivo.

Research Area

Cancer Biology, Immunology & Inflammation

Key Properties

• CAS Number: 2456295-45-5
• MW: 801.84
• Formula: C₃₉H₃₅N₃O₁₂S₂
• SMILES: N(S(=O)(=O)C1=CC=C(OC)C=C1)(CC(O)=O)C=2C3=C(C(N(S(=O)(=O)C4=CC=C(OC)C=C4)CC(O)=O)=CC2CCCN5C(=O)C=6C(C5=O)=CC=CC6)C=CC=C3
• Target: Others,Nrf2

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155007330