Keap1-IN-1

SKU: orb2945466

Description

Keap1-IN-1 (Compound 27) is a covalent Keap1 inhibitor that selectively targets the Cys151 residue, disrupting the Keap1-Nrf2 interaction to activate the Nrf2/ARE pathway. It induces NQO1 expression (EC50 = 160 nM) and demonstrates cytotoxicity in U2OS cells (EC50 = 527 nM), making it a valuable chemical probe for studying oxidative stress responses in cancer and neurodegenerative disease research.

Research Area

Cancer Biology

Key Properties

• MW: 531.434
• Formula: C₁₇H₂₁Cl₂N₂O₅PS₃
• SMILES: CCP1(=O)CCN(CC1)C2=C(N=C(S2)S(=O)(=O)CC)S(=O)(=O)C3=C(C(=CC=C3)Cl)Cl
• Target: Nrf2,Reductase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172676942