KDM5-C49 HCl

SKU: orb1745244

Description

KDM5-C49 HCl (KDOAM-20 hydrochloride) is a potent and selective KDM5 demethylase inhibitor with the free base CAS 1596348-16-1. It is a research candidate for cancer therapy, with studies demonstrating its activity in disrupting histone methylation and cancer cell proliferation in both cellular and animal models.

Research Area

Epigenetics & Chromatin

Key Properties

• MW: 344.84
• Purity: 98.59% (May vary between batches)
• Formula: C₁₅H₂₅ClN₄O₃
• SMILES: Cl.CCN(CCN(C)C)C(=O)CNCc1cc(ccn1)C(O)=O
• Target: Histone Demethylase
• Solubility: DMSO:9 mg/mL (26.1 mM)

Bioactivity

• Target IC50:
  KDM5C:100 nM|KDM5B:160 nM|KDM5A:40 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KDOAM 20 Hydrochloride, KDOAM20 Hydrochloride, KDOAM-20 Hydrochloride, KDOAM-20 hydrochloride, KDM5, KDM5-C49 HCl(1596348-16-1 Free base), KDM5-C49 HCl, KDM5-C49 HCl(1596348-16-1 Free base), HistoneDemethylase, Histone Demethylase

Compound Identifiers

PubChem CID

169553387