KDM4D-IN-1

SKU: orb1303055

Description

KDM4D-IN-1 is a potent and selective small molecule inhibitor of the histone demethylase KDM4D, exhibiting an IC50 of 0.41±0.03 μM. This compound is a valuable chemical probe for epigenetic research, enabling the study of KDM4D's role in gene regulation and cellular processes in both in vitro and in vivo experimental models.

Research Area

Epigenetics & Chromatin, Metabolism Research

Key Properties

• CAS Number: 2098902-68-0
• MW: 225.21
• Purity: 100.00% (May vary between batches)
• Formula: C₁₁H₇N₅O
• SMILES: Cc1nn2c(nc(O)c3cccnc23)c1C#N
• Target: Histone Demethylase
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (2.22 mM);DMSO:11 mg/mL (48.84 mM)

Bioactivity

• Target IC50:
  KDM4D:0.41±0.03 μM
• In Vitro:
  KDM4D-IN-1 almost not inhibits KDM2B, KDM3B, and KDM5A (IC50>10 μM), indicating that KDM4D-IN-1 has a good specific for KDM4D against other selected KDMs.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, HistoneDemethylase, Histone Demethylase, inhibit, KDM4D-IN-1, KDM4D, KDM4D IN 1, KDM4DIN1, KDM-4D-IN-1

Compound Identifiers

PubChem CID

137174251