KDM2/7-IN-1

SKU: orb1704003

Description

KDM2/7-IN-1 (TC-E 5002) is a selective inhibitor of the KDM2/7 histone demethylase subfamily. It demonstrates potent anti-proliferative effects in HeLa and KYSE-150 cancer cell lines in vitro, making it a valuable chemical probe for epigenetic mechanisms and oncology research.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1453071-47-0
• MW: 285.38
• Purity: 99.87% (May vary between batches)
• Formula: C₁₅H₂₇NO₄
• SMILES: O=C(O)CCN(O)C(=O)CCCCCCCCC1CC1
• Target: Histone Demethylase
• Solubility: DMSO:24 mg/mL (84.1 mM)

Bioactivity

• Target IC50:
  KDM6A:>100 μM|KDM4C:83 μM|KDM4A:>120 μM|KDM2A:6.8 μM|KDM5A:55 μM|KDM7A:0.2 μM|KDM7B:1.2 μM
• In Vitro:
  KDM2/7-IN-1 exhibits anti-proliferative activity in N2a cells with a GI50 value of 86 μM . In HeLa and KYSE150 cells, KDM2/7-IN-1 significantly inhibits cell growth and is associated with elevated H3K27me2 levels . After KDM2/7-IN-1 treatment, the expression of the E2F1 gene in HeLa cells markedly decreases, and the cell cycle arrests at the G0/G1 phase .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KDM2/7 IN 1, KDM2/7IN1, KDM-2/7-IN-1, KDM2/7-IN-1, TC-E 5002, TC-E5002, TC-E-5002

Compound Identifiers

PubChem CID

71735843