KD-026

SKU: orb1305038

Description

KD-026 (SLx-4090) is a potent and selective microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 8.0 nM. This small molecule is utilized in preclinical research for type 2 diabetes, investigating mechanisms related to lipid metabolism and chylomicron production in both in vitro and in vivo models.

Research Area

Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 913541-47-6
• MW: 546.54
• Purity: 99.73% (May vary between batches)
• Formula: C₃₁H₂₅F₃N₂O₄
• SMILES: COc1cccc(C(=O)Nc2ccc3CN(CCc3c2)C(=O)Oc2ccccc2)c1-c1ccc(cc1)C(F)(F)F
• Target: CETP
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.66 mM);DMSO:55 mg/mL (100.63 mM)

Bioactivity

• Target IC50:
  ApoB:9.6 nM|MTP:8.0 nM
• In Vivo:
  In rats, KD-026 (30 mg/kg) reduced postprandial lipids by 50% (ED50 = 7 mg/kg).
• In Vitro:
  KD-026 shows inhibitory effect against apolipoprotein B (IC50 = 9.6 nM) but no effect on apolipoprotein A1 secretion in Caco-2 cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, enterocytic-specific, inhibit, MTP inhibitor, MTP, KD026, KD-026, KD 026, microsomal triglyceride transfer protein, dyslipidemia, SLx4090, SLx-4090, SLx 4090

Compound Identifiers

PubChem CID

53497429