KB528

SKU: orb3211264

Description

KB528 is an inhibitor of the p300/CBP histone acetyltransferase (KAT) that exhibits low nanomolar IC50 values against human p300 and CBP, displaying selectivity over other KAT family members. It regulates the IRF4 transcription network, downregulating the expression of IRF4, MYC, CAV2, IGLL5, and reducing IKZF3 protein levels. KB528 effectively induces apoptosis in multiple myeloma cells and is applicable in research related to multiple myeloma.

Key Properties

• CAS Number: 3082090-83-0
• MW: 464.56
• Formula: C₂₈H₂₈N₆O
• SMILES: [C@H](NC[C@@H](C)C1=CC=C(C#N)C=C1)([C@]2(OC=3C(NC2)=CC(=CN3)C=4C=NN(C)C4)[H])C5=CC=CC=C5
• Target: Histone Acetyltransferase,IKZF,Apoptosis,Epigenetic Reader Domain

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Histone Acetyltransferase,IKZF,Apoptosis,Epigenetic Reader Domain