KB02-JQ1

SKU: orb1988269

Description

KB02-JQ1 is a potent and selective PROTAC degrader that specifically targets BRD4 for ubiquitin-mediated degradation by covalently engaging the E3 ligase DCAF16. This molecular glue compound exhibits enhanced stability and is a valuable chemical tool for studying BRD4 function in cancer biology and epigenetics research, both in vitro and in vivo.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2384184-44-3
• MW: 796.77
• Formula: C₃₈H₄₃Cl₂N₇O₆S
• SMILES: Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCOCCOCCNC(=O)COc1ccc3N(CCCc3c1)C(=O)CCl)c1nnc(C)n-21)c1ccc(Cl)cc1 |c:8|
• Target: PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

137347731