KB-15

SKU: orb3136908

Description

KB-15 is a STAT3 inhibitor exhibiting significant antiproliferative activity against AGS gastric cancer cells (IC50 = 0.29 μM) and BGC-823 gastric cancer cells (IC50 = 0.65 μM). It exerts its antitumor effects by inhibiting STAT3 phosphorylation, downregulating HO-1 expression, and promoting intracellular reactive oxygen species (ROS) accumulation. Additionally, KB-15 induces G0/G1 phase cell cycle arrest and apoptosis while hindering colony formation and migration in gastric cancer cells. In the BGC-823 subcutaneous xenograft model, KB-15 demonstrates excellent antitumor efficacy.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• Target: Apoptosis,STAT,ROS,PARP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Apoptosis,STAT,ROS,PARP