KAT6-IN-1

SKU: orb1982278

Description

KAT6-IN-1 is a potent, selective, and orally bioavailable inhibitor of the histone acetyltransferases KAT6A and KAT6B. It demonstrates antitumor efficacy in cellular assays and in vivo models, supporting its use in oncology research for studying epigenetic mechanisms in cancer.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2569008-99-5
• MW: 414.43
• Purity: 99.86% (May vary between batches)
• Formula: C₁₉H₁₈N₄O₅S
• SMILES: O=S(=O)(NC1=NOC2=CC(=CC(OC)=C21)CN3N=CC=C3)C=4C=CC=CC4OC
• Target: Histone Acetyltransferase
• Solubility: DMSO:3 mg/mL (7.24 mM)

Bioactivity

• In Vivo:
  In the mouse ST340 Parazacco spilurus subsp. spilurus transplantation model, KAT6-IN-1 (3 mg/kg, orally administered once daily for 21 days) demonstrated antitumor activity .
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• In Vitro:
  The combination of KAT6-IN-1 and Palbociclib exerts synergistic inhibitory effects on T47D, ZR-75-1, CAMA1, and MCF7 cancer cells .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Prifetrastat, PF07248144, PF-07248144

Compound Identifiers

PubChem CID

155411211