KARS-IN-1

SKU: orb3174998

Description

KARS-IN-1 (152) is an AKR1C3-dependent KARS inhibitor with an AC50 of 9.1 nM for human KARS. It exhibits antiproliferative activity in both H460 (NRF2 pathway-mutant cell line with high AKR1C3 expression) and Hara (NRF2 pathway wild-type cell line with low AKR1C3 expression), with AC50 values of 21 nM and 16 nM, respectively. KARS-IN-1 is applicable in non-small cell lung cancer (NSCLC) research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2579083-99-9
• MW: 387.43
• Formula: C₂₁H₂₃F₂N₃O₂
• SMILES: O[C@@H]1CC2(NC=3C1=CC(F)=CC3)CCN(C(NCC4=CC=C(F)C=C4)=O)CC2
• Target: Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ras