Kansuinine A

SKU: orb1297099

Description

Kansuinine A is a bioactive compound isolated from Euphorbia kansui roots. It inhibits IL-6-induced STAT3 activation via ERK1/2 pathway stimulation, making it a useful research tool for studying inflammation, cancer signaling, and autoimmune diseases in cellular models.

Research Area

Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 57701-86-7
• MW: 730.75
• Purity: 99.96% (May vary between batches)
• Formula: C₃₇H₄₆O₁₅
• SMILES: [H][C@]12O[C@](O)([C@H](C)C1=O)[C@]1(C[C@H](C)[C@H](OC(C)=O)[C@]1([H])[C@@H](OC(C)=O)C(=C)[C@H](OC(C)=O)[C@@H](OC(=O)c1ccccc1)[C@@H](OC(C)=O)C2(C)C)OC(C)=O
• Target: Interleukin,IL Receptor,STAT
• Solubility: DMSO:≥ 100 mg/mL (136.85 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.74 mM)

Bioactivity

• In Vitro:
  Kansuinine A markedly promoted SPL proliferation and NO production by PMphi at concentrations from 0.78 to 12.50 microg/mL.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IL Receptor, Inhibitor, Interleukin, Interleukin Related, Kansuinine A, inhibit, ILReceptor, IL-6, STAT3

Compound Identifiers

PubChem CID

11366139