Kanamycin A

SKU: orb1992991

Description

Kanamycin A (KanamycinA) is an aminoglycoside antibiotic with antibacterial and antiviral activity that inhibits bacterial and viral replication.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 59-01-8
• MW: 484.5
• Purity: 99.59%
• Formula: C₁₈H₃₆N₄O₁₁
• SMILES: O([C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](N)C[C@H]1N)[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O
• Target: Antibiotic,Antibacterial
• Solubility: DMSO:Soluble;H2O:60 mg/mL (123.84 mM)

Bioactivity

• In Vivo:
  Kanamycin A administered intravenously at doses of 2 mg/kg and 4 mg/kg once a day, Six times a week for three weeks effectively inhibite the growth of Mycobacterium bovis in the lungs and spleens of mice. Kanamycin A administered intravenously in a single dose (3 hours post-infection) at 1.25 mg/kg and 5 mg/kg significantly reduce the colonization of K. pneumoniae DT-S in the lungs, trachea and blood of mice and this reduction was proportional to the administered dose, while increasin the survival rate of mice.
• In Vitro:
  Kanamycin A (0.1-100 μg/ml; 2 weeks of treatment) showed good antimicrobial activity against a wide range of mycobacterial strains in vitro with a minimum inhibitory concentration (MIC) of 1-5 μg/ml.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Kanamycin free base, Kanamycin, Kanamycin A, KanamycinA, Kanamycine, Kantrex

Compound Identifiers

PubChem CID

6032