Kanamycin A

SKU: orb1992991

Description

Kanamycin A is a broad-spectrum aminoglycoside antibiotic that inhibits protein synthesis, thereby blocking bacterial and viral replication. It is widely used in molecular biology for in vitro selection and in research involving bacterial infection models, both in cell culture and in vivo studies.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 59-01-8
• MW: 484.5
• Formula: C₁₈H₃₆N₄O₁₁
• SMILES: O([C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](N)C[C@H]1N)[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O
• Target: Antibiotic|||Antibacterial
• Solubility: DMSO:Soluble;H2O:60 mg/mL (123.84 mM)

Bioactivity

• In Vivo:
  Kanamycin A administered intravenously at doses of 2 mg/kg and 4 mg/kg once a day, six times a week for three weeks effectively inhibited the growth of Mycobacterium bovis in the lungs and spleens of mice. Kanamycin A administered intravenously in a single dose (3 hours post-infection) at 1.25 mg/kg and 5 mg/kg significantly reduced the colonization of K. pneumoniae DT-S in the lungs, trachea and blood of mice and this reduction was proportional to the administered dose, while increasing the survival rate of mice.
  Read more...
• In Vitro:
  Kanamycin A (0.1-100 μg/mL; 2 weeks of treatment) showed good antimicrobial activity against a wide range of mycobacterial strains in vitro with a minimum inhibitory concentration (MIC) of 1-5 μg/mL.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Kanamycin free base, Kanamycin, Kanamycin A, KanamycinA, Kanamycine, Kantrex

Compound Identifiers

PubChem CID

6032