KAI-11101

SKU: orb2945704

Description

KAI-11101 is a potent, brain-penetrant dual leucine zipper kinase (DLK/MAP3K12) inhibitor with a Ki of 0.7 nM. It blocks paclitaxel-induced c-Jun phosphorylation (IC50=95 nM) and MAPK pathway activation, making it a valuable tool for studying neuroprotection in models of chemotherapy-induced peripheral neuropathy and other neurological disorders.

Research Area

Signal Transduction

Key Properties

• CAS Number: 3099935-02-8
• MW: 469.433
• Formula: C₂₁H₂₃F₄N₅O₃
• SMILES: CCN1C2=C(C=CN(C2=O)[C@@H]3CCC(C[C@@H]3OC)(F)F)C(=N1)C4=CC(=C(N=C4)N)OC(F)F
• Target: MAP3K,MAPK,p38 MAPK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172655160