Kahalalide F

SKU: orb3174041

Description

Kahalalide F is a novel marine-derived antitumor agent known for inhibiting DNA synthesis. It exhibits cytotoxicity that is not correlated with the expression levels of the multidrug resistance gene MDR1 or the tyrosine kinase HER2/NEU, and is only slightly related to the expression of the anti-apoptotic protein BCL-2. Kahalalide F hinders the PI3K-Akt signaling pathway by depleting ErbB3. Its effects are rapidly activated with short pulse treatments. The compound primarily induces cell death through oncosis (cellular swelling) in tumor cells. Kahalalide F can be utilized in studies of prostate cancer, breast cancer, vulvar cancer, and non-small cell lung cancer.

Key Properties

• CAS Number: 149204-42-2
• MW: 1477.9
• Formula: C₇₅H₁₂₄N₁₄O₁₆
• SMILES: C([C@H](NC([C@@H](NC([C@@H](NC([C@H](NC(CCCC(C)C)=O)[C@@H](C)C)=O)[C@@H](C)O)=O)C(C)C)=O)[C@@H](C)C)(=O)N1[C@@H](C(N[C@H](C(N[C@@H](C(N[C@H]2C(=O)N[C@]([C@H](CC)C)(C(=O)N[C@H](C(C)C)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N/C(=C\C)/C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]2C)[H])=O)[C@H](CC)C)=O)CCCN)=O)CCC1
• Target: PI3K,Akt,EGFR,DNA/RNA Synthesis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

PI3K,Akt,EGFR,DNA/RNA Synthesis