Kaempferol 3-neohesperidoside

SKU: orb1297315

Description

Kaempferol 3-O-neohesperidoside is a flavonoid glycoside that exhibits insulin-like activity, as demonstrated in ex vivo studies using rat soleus muscle. This compound is a valuable research tool for investigating glucose metabolism, insulin signaling pathways, and potential therapeutic applications in metabolic disorders.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 32602-81-6
• MW: 594.52
• Purity: 98.34% (May vary between batches)
• Formula: C₂₇H₃₀O₁₅
• SMILES: C[C@@H]1O[C@@H](O[C@H]2[C@H](Oc3c(oc4cc(O)cc(O)c4c3=O)-c3ccc(O)cc3)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O
• Target: GSK-3,PI3K,IGF-1R,MEK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.36 mM);DMSO:55 mg/mL (92.51 mM)

Bioactivity

• In Vitro:
  A stimulatory effect of Kaempferol 3-neohesperidoside ( 1) on glucose uptake (35% and 21%) was observed when the rat soleus muscle was incubated with 1 and 100 nM of this flavonoid glycoside, respectively. The concentration-response curve of insulin showed a stimulatory effect at 3.5 and 7.0 nM (42% and 50%) on glucose uptake when compared with the control group. The effect of Kaempferol 3-neohesperidoside on glucose uptake was completely nullified by pretreatment with LY294002, an inhibitor of phosphoinositide 3-kinase (PI3K), and RO318220, an inhibitor of protein kinase C (PKC). However, no significant change occurred on glucose uptake stimulated by Kaempferol 3-neohesperidoside when muscles were pretreated with PD98059, an inhibitor of mitogen-activated protein kinase (MEK), and cycloheximide, an inhibitor of protein synthesis. Kaempferol 3-neohesperidoside and insulin (7 nM) did not show a synergistic effect on glucose uptake. Additionally, 100 mg/kg of Kaempferol 3-neohesperidoside by oral gavage was able to increase glycogen content in the muscle
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PI3K, MEK, Inhibitor, GSK-3, GSK3, Kaempferol 3 neohesperidoside, Kaempferol 3-O-neohesperidoside, Kaempferol 3neohesperidoside, Kaempferol 3-neohesperidoside, inhibit

Compound Identifiers

PubChem CID

5318761