Kadsurin

SKU: orb1297318

Description

Kadsurin exhibits antioxidant properties by inducing hepatic enzymes that scavenge reactive oxygen species. This lignan has shown potential as a chemopreventive agent and antitumor promoter in research, with studies investigating its mechanisms in both in vitro and in vivo models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 51670-40-7
• MW: 458.5
• Purity: 99.63% (May vary between batches)
• Formula: C₂₅H₃₀O₈
• SMILES: [H][C@@]1(C)Cc2cc(OC)c(OC)c(OC)c2-c2c(OC)c3OCOc3cc2[C@]([H])(OC(C)=O)[C@]1([H])C
• Target: Antioxidant
• Solubility: DMSO:11 mg/mL (23.99 mM)

Bioactivity

• In Vitro:
  Two new lignans, interiotherins C (1) and D (2), together with the known compounds interiorin (3), heteroclitin F (4), neokadsuranin (5), heteroclitin D (6), Kadsurin (7), gomisin A (8), schisandrin C (9), interiotherin A (10), angeloylgomisin R (11), gomisin G (12), interiotherin B (13), and gomisin C (14), were isolated from the stems of Kadsura interior. The structures and stereochemistries of the new compounds were determined from mass, CD, and NMR spectral data. Fourteen neolignans were screened as potential antitumor promoters by examining their ability to inhibit Epstein-Barr virus early antigen (EBV-EA) activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. Neokadsuranin (5) and schisandrin C (9) were the most potent compounds.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Kadsurin, inhibit, Antioxidant

Compound Identifiers

PubChem CID

171064