K-858

SKU: orb1304516

Description

K858 Racemic is a selective, ATP-noncompetitive inhibitor of the mitotic kinesin Eg5. It is used in biochemical and cellular research to study mitosis, cell cycle arrest, and has been applied in both in vitro and in vivo cancer model studies.

Research Area

Cell Biology

Key Properties

• CAS Number: 72926-24-0
• MW: 277.35
• Purity: >98%
• Formula: C₁₃H₁₅N₃O₂S
• SMILES: CC(=O)NC1=NN(C(C)=O)C(C)(S1)C1=CC=CC=C1
• Target: Cytoskeleton
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml).

Bioactivity

• Target IC50:
  EG5:1.3 μM
• In Vivo:
  K858 exhibits antitumor activity and induces mitotic arrest in a human tumor xenograft mouse model. K858 exhibits antitumor activity and induces mitotic arrest in human xenograft tumor models.
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• In Vitro:
  K858 is an ATP-uncompetitive inhibitor of Eg5 that is at least 150-fold more selective for Eg5 than other members of the kinesin superfamily. K858 induces mitotic arrest and growth inhibition through the activation of the Mad2-mediated spindle checkpoint. K858 induces mitotic cell death in Y cells but not in normal cells. K858 induces mitotic arrest, apoptosis, and cell growth inhibition and has no effect on microtubule polymerization.
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Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Kinesin, K858, K-858, K858 (Racemic), K-858 (Racemic), K858 Racemic, K 858, inhibit, Eg5 ATPase, Apoptosis, Racemic

Compound Identifiers

PubChem CID

2930014