K67

SKU: orb1700256

Description

K67 is a competitive inhibitor of the Nrf2-ETGE/Keap1 interaction. It suppresses the proliferation of hepatocellular carcinoma (HCC) cells characterized by high levels of S351-phosphorylated p62, making it a useful research tool for studying Nrf2 signaling and liver cancer in vitro.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 2046250-48-8
• MW: 582.69
• Purity: 98.43% (May vary between batches)
• Formula: C₂₉H₃₀N₂O₇S₂
• SMILES: O=C(C)CC=1C=C(NS(=O)(=O)C2=CC=C(OCC)C=C2)C=3C=CC=CC3C1NS(=O)(=O)C4=CC=C(OCC)C=C4
• Target: p62,Nrf2
• Solubility: 10% DMSO+90% Corn Oil:5 mg/mL (8.58 mM);DMSO:80 mg/mL (137.29 mM)

Bioactivity

• In Vitro:
  METHODS: Huh7 cells expressing S351E were treated with K67 (50 μM, 4 h), and the cells were treated with or without lactacystin (10 μM) for 8 hours. Immunoblot analyses were performed for immunosuppressants with anti-Nrf2 antibodies. RESULTS:Treatment of Huh1 cells with K67 greatly inhibited the interaction between p62 phosphorylation and Keap1, and K67 significantly promoted ubiquitination of Nrf2.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

K 67, K67, K-67, Keap1-Nrf2

Compound Identifiers

PubChem CID

119057445