K145 hydrochloride

SKU: orb1296177

Description

K145 hydrochloride is an orally active, substrate-competitive, and selective SphK2 inhibitor (IC₅₀ = 4.3 µM, Kᵢ = 6.4 µM). It exhibits potent antitumor activity by inducing apoptosis, making it a valuable tool for oncology research in both cellular and animal models of cancer.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1449240-68-9
• MW: 384.92
• Purity: 99.80% (May vary between batches)
• Formula: C₁₈H₂₅ClN₂O₃S
• SMILES: Cl.CCCCOc1ccc(CC\C=C2/SC(=O)N(CCN)C2=O)cc1
• Target: S1P Receptor,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.6 mM);H2O:125 mg/mL (324.74 mM);DMSO:45 mg/mL (116.91 mM)

Bioactivity

• Target IC50:
  SPHK2:4.30 μM|SPHK2:6.4 µM(Ki)
• In Vitro:
  K145 inhibited the activity of SphK2 in a dose-dependent manner with an IC50 of 4.30 uM. The Lineweaver-Burk analysis revealed a Ki of 6.4±0.7 uM for SphK2 and indicated that K145 is a substrate competitive inhibitor (with sphingosine). K145 accumulates in U937 cells, suppresses the S1P level, and inhibits SphK2. K145 also exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells, and that these effects may be through the inhibition of downstream ERK and Akt signaling pathways.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antitumor, anti-proliferative, Apoptosis, apoptotic, Akt, ERK, Inhibitor, oral, K 145, K 145 Hydrochloride, K145, K-145, K145 hydrochloride, K145 Hydrochloride, K-145 Hydrochloride, K-145 hydrochloride, inhibit, SphK2, SphK, sphingosine, Sphingosine kinase, S1PReceptor, substrate-competitive, S1P Receptor, S1P

Compound Identifiers

PubChem CID

76849910