K00135

SKU: orb1305040

Description

K00135 is a selective Pim kinase inhibitor used in cancer research. It has demonstrated activity in both in vitro and in vivo studies, supporting its investigation in areas such as gastric cancer and leukemia therapeutics.

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 869650-21-5
• MW: 306.36
• Purity: 98.16% (May vary between batches)
• Formula: C₁₈H₁₈N₄O
• SMILES: N(CC1CC1)C2=NN3C(=CN=C3C=C2)C4=CC(C(C)=O)=CC=C4
• Target: Pim
• Solubility: DMSO:4.4 mg/mL (14.36 mM)

Bioactivity

• In Vitro:
  K00135 dose-dependently impairs the survival of murine Ba/F3 cells that have been rendered cytokine independent by overexpression of human PIMs. K00135 impairs survival and clonogenic growth of a panel of human acute leukemia cells. Exposure of K00135 significantly suppresses in vitro growth of leukemic blasts from five acute myelogenous leukemia patients but not of normal umbilical cord blood mononuclear cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Imidazol[1,2-b]pyridazine 1, IMIDAZOPYRIDAZIN 1, K00135, K-00135, K 00135, Pim

Compound Identifiers

PubChem CID

5459373