K-Ras-PDEδ-IN-1

SKU: orb1298736

Description

K-Ras-PDEδ-IN-1 is a high-affinity inhibitor (Kd = 8 nM) that targets the farnesyl-binding site of PDEδ, disrupting the K-Ras-PDEδ interaction. This tool compound is valuable for in vitro biochemical studies and cellular research exploring oncogenic Ras signaling pathways and potential therapeutic strategies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1841464-21-8
• MW: 447.5
• Purity: 99.74% (May vary between batches)
• Formula: C₂₅H₂₆FN₅O₂
• SMILES: Cc1ccc(cc1)-n1cc2c(C)nn(CCCC(=O)NCCc3ccc(F)cc3)c(=O)c2n1
• Target: PDE
• Solubility: DMSO:4.48 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  PDE4:8.3 nM (Kd)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cancer, Inhibitor, K Ras PDEδ IN 1, inhibit, K-Ras-PDEdelta-IN-1, KRasPDEδIN1, K-Ras-PDEδ-IN-1, PDEδ, PDE, phosphodiesterase, Phosphodiesterase (PDE), pyrazolopyridazinone-based

Compound Identifiers

PubChem CID

118583099