K-Ras-PDEδ-IN-1

SKU: orb1298736

Description

K-Ras-PDEδ-IN-1 is a high-affinity inhibitor (Kd = 8 nM) that targets the farnesyl-binding site of PDEδ, disrupting the K-Ras-PDEδ interaction. This tool compound is valuable for in vitro biochemical studies and cellular research exploring oncogenic Ras signaling pathways and potential therapeutic strategies.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1841464-21-8
• MW: 447.5
• Purity: 99.74% (May vary between batches)
• Formula: C₂₅H₂₆FN₅O₂
• SMILES: Cc1ccc(cc1)-n1cc2c(C)nn(CCCC(=O)NCCc3ccc(F)cc3)c(=O)c2n1
• Target: PDE
• Solubility: DMSO:4.48 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  PDE4:8.3 nM (Kd)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cancer, Inhibitor, K Ras PDEδ IN 1, inhibit, K-Ras-PDEdelta-IN-1, KRasPDEδIN1, K-Ras-PDEδ-IN-1, PDEδ, PDE, phosphodiesterase, Phosphodiesterase (PDE), pyrazolopyridazinone-based

Compound Identifiers

PubChem CID

118583099