K-Ras ligand-Linker Conjugate 2

SKU: orb1988273

Description

K-Ras ligand-Linker Conjugate 2 is a bifunctional compound consisting of a K-Ras ligand and a PROTAC linker. It is designed to recruit E3 ligases such as VHL and CRBN for the synthesis of potent PROTAC degraders, like PROTAC K-Ras Degrader-1, which demonstrates ≥70% degradation efficacy in SW1573 cell-based studies.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• MW: 822.99
• Formula: C₄₅H₅₈N₈O₇
• SMILES: NCCOCCOCCOCCO[C@H]1CN(C)[C@H](COC2=NC3=C(CCN(C4=CC=CC5=C4C=CC=C5)C3)C(N6CCN(C(OCC7=CC=CC=C7)=O)[C@@H](CC#N)C6)=N2)C1
• Target: Target Protein Ligand-Linker Conjugates,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

145712385