K-Ras-IN-3

SKU: orb2664290

Description

K-Ras-IN-3 (compound 3) is a potent and selective inhibitor of the GDP-bound KRAS G12V mutant, demonstrating an IC50 of 0.371 nM. This small molecule is a valuable chemical probe for investigating KRAS-driven oncogenesis in both cellular and animal models of cancer.

Research Area

Signal Transduction

Key Properties

• CAS Number: 3024991-82-7
• MW: 685.62
• Formula: C₃₄H₂₉F₆N₅O₄
• SMILES: C(C(O)=O)(F)(F)F.C(OC1=NC2=C(C(N(C)[C@@H]3[C@@H](F)C3)=N1)C=NC(=C2F)C=4C5=C(C=C(O)C4)C=CC(F)=C5C#C)C67N(CC(=C)C6)CCC7
• Target: Kras,Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172419443