K-80003

SKU: orb1709356

Description

K-80003 (TX-803) is a potent small molecule RXRα regulator that suppresses tumor cell proliferation by inhibiting TRxrα-mediated Akt activation. It is a valuable research tool for studying oncogenic signaling pathways and has demonstrated anti-proliferative effects in various in vitro cancer cell models.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1292821-90-9
• MW: 336.4
• Purity: 99.76% (May vary between batches)
• Formula: C₂₂H₂₁FO₂
• SMILES: CC(C)c1ccc(\C=C2\C(C)=C(CC(O)=O)c3cc(F)ccc23)cc1
• Target: Akt|||RAR/RXR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (7.43 mM);DMSO:60 mg/mL (178.36 mM)

Bioactivity

• In Vivo:
  K-80003, a potent inhibitor of AKT activation by all-trans-retinoic acid, exhibits enhanced efficacy in inhibiting tRXRα-dependent AKT activation and tRXRα tumor growth in animals. K-80003 has high affinity for RXRα but lacks COX inhibitory activity .
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• In Vitro:
  In MCF-7 cells, cotreatment with K-80003 inhibits the TNFα-induced colocalization of tRXRα with p85α in the cytoplasm, leading to tRXRα nuclear localization. Western blotting reveals that the K-80003-stabilized tetrameric form of tRXRα is exclusively present in the nuclear fraction, while the tRXRα monomer is distributed in both nuclear and cytoplasmic fractions .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Akt, K 80003, K80003, K-80003, TX 803, TX803, TX-803, retinoid X receptor α, RXR, RAR

Compound Identifiers

PubChem CID

46224594