JZL 184

SKU: orb1300664

Description

JZL 184

Research Area

Metabolism Research

Key Properties

• CAS Number: 1101854-58-3
• MW: 520.49
• Purity: 97.60%
• Formula: C₂₇H₂₄N₂O₉
• SMILES: OC(C1CCN(CC1)C(=O)Oc1ccc(cc1)[N+]([O-])=O)(c1ccc2OCOc2c1)c1ccc2OCOc2c1
• Target: MAGL,Lipase
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.34 mM);DMSO:93 mg/mL (178.68 mM)

Bioactivity

• Target IC50:
  MAGL:8 nM
• In Vivo:
  JZL184 produced a rapid and sustained blockade of brain 2-AG hydrolase activity in mice, resulting in eight-fold elevations in endogenous 2-AG levels that are maintained for at least 8 h. JZL184-treated mice showed a wide array of CB1-dependent behavioral effects, including analgesia, hypomotility and hypothermia, that suggest a broad role for 2-AG–mediated endocannabinoid signaling throughou the mammalian nervous system.
• In Vitro:
  JZL184 is a useful tool for studyin the effects of endogenous 2-AG signaling. JZL184 displays time-dependent Inhibition of MAGL and exhibits >300-fold selectivity for MAGL over FAAH in vitro JZL184 does not interact with CB1 or CB2 receptors and does not inhibi the 2-AG biosynthetic enzymes diacylglycerol lipase- and diacylglycerol lipase-β, o the arachidonic acid–mobilizing enzyme cytosolic phospholipase A2 group IVA.
• Cell Research:
  1 × 105 cells are split into four-well chamber slides and incubated with culture medium containing BrdU for 4 h. BrdU staining is performed followin the manufacturer's instructions.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

MAGL, hydrolysis, Inhibitor, neurons, JZL 184, JZL184, JZL-184, Monoacylglycerol lipase, inhibit, analgesia, antinociceptive, 2-Arachidonoylglycerol

Compound Identifiers

PubChem CID

25021165