JY-2

SKU: orb1744054

Description

JY-2 is a selective, orally bioavailable FoxO1 inhibitor with demonstrated antidiabetic activity. It is a valuable research tool for investigating FoxO1's role in metabolic disorders like diabetes and inflammatory conditions such as psoriasis, with utility in both in vitro and in vivo studies.

Research Area

Cell Biology

Key Properties

• CAS Number: 339103-05-8
• MW: 292.12
• Purity: 99.91% (May vary between batches)
• Formula: C₁₃H₇Cl₂N₃O
• SMILES: ClC1=CC(Cl)=C(C=C1)C1=NC(=NO1)C1=NC=CC=C1
• Target: FOXO
• Solubility: DMSO:80 mg/mL (273.86 mM)

Bioactivity

• In Vivo:
  JY-2 exhibits anti-diabetic effects in mice, administered orally at doses of 50-200 mg/kg, either three times over two days or daily for 4 weeks .
• In Vitro:
  JY-2, at concentrations ranging from 10 to 100 μM for 24 hours, reduces palmitic acid induced lipotoxicity in HepG2 and INS-1 cells .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Forkhead box protein O1 (FOXO1)

Compound Identifiers

PubChem CID

702923