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JWJ-01-378

SKU: orb3136919

Description

JWJ-01-378 is a selective TRK PROTAC degrader. It effectively degrades wild-type TRK and TPM3-TRKA fusion proteins while inhibiting downstream pERK signaling, but shows limited degradation effects on TRK inhibitor-resistant mutants and ALK fusion proteins. Additionally, JWJ-01-378 effectively suppresses cancer cell proliferation.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

TargetERK,Trk receptor,PROTACs

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information