JWG-071

SKU: orb1707571

Description

JWG-071 is the first reported chemical probe demonstrating selectivity for ERK5 kinase. It functions as a BET-selective inhibitor with a 1 µM IC50 for BRD4, paradoxically enhancing ERK5 activity. This probe is used in vitro to study kinase signaling crosstalk and BET bromodomain biology in cancer research.

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 2250323-50-1
• MW: 612.77
• Purity: 99.83% (May vary between batches)
• Formula: C₃₄H₄₄N₈O₃
• SMILES: CCC(C)N1c2ccccc2C(=O)N(C)c2cnc(Nc3ccc(cc3OC)C(=O)N3CCC(CC3)N3CCN(C)CC3)nc12
• Target: Epigenetic Reader Domain,ERK
• Solubility: DMSO:61.28 mg/mL (100 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.26 mM)

Bioactivity

• Target IC50:
  ERK5:88 nM
• In Vitro:
  JWG-071 demonstrates IC50 values of 88 nM and 109 nM for inhibiting ERK5 and LRRK2, respectively.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ERK5, EpigeneticReaderDomain, Epigenetic Reader Domain, JWG 071, JWG071, JWG-071, BRD4

Compound Identifiers

PubChem CID

131842089