JW 67

SKU: orb1305788

Description

JW 67 is a small molecule inhibitor of the canonical Wnt/β-catenin pathway. It acts by rapidly decreasing active β-catenin levels, leading to the downregulation of target genes such as AXIN2, SP5, and NKD1. This inhibitor is a valuable tool for studying Wnt signaling in both cellular assays and in vivo disease models, including cancer and stem cell research.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 442644-28-2
• MW: 394.38
• Purity: 99.02% (May vary between batches)
• Formula: C₂₁H₁₈N₂O₆
• SMILES: O=C1Nc2ccccc2C11OCC2(CO1)COC1(OC2)C(=O)Nc2ccccc12
• Target: Wnt/beta-catenin
• Solubility: DMSO:60 mg/mL (152.14 mM);10% DMSO+90% Saline:2.5 mg/mL (6.34 mM)

Bioactivity

• Target IC50:
  Wnt:1.17μM
• In Vitro:
  JW 67 inhibits the canonical Wnt signaling with an IC50 of 1.17μM. JW 67 (1 μM) increased concentration of AXIN2 and decreased the active form of β-catenin. JW 67 (10 or 25μM) reduced growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK-3b, Inhibitor, JW67, JW-67, JW 67, multiprotein, inhibit, CK1, complex, beta-catenin, betacatenin, bcatenin, AXIN, APC, Wnt/β-catenin, Wnt/betacatenin, Wnt/b-catenin, Wnt, βcatenin, β-catenin

Compound Identifiers

PubChem CID

644733