Juglone

• Catalog Number: orb1303312
• Category: Small Molecules
• Description: Juglone
• CAS Number: 481-39-0
• Purity: 98.73%
• MW: 174.15
• SMILES: O=C1C=2C(C(=O)C=C1)=C(O)C=CC2
• Formula: C₁₀H₆O₃
• Biological Activity: Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.