JTT-654

SKU: orb2565908

Description

JTT-654 is a potent, selective, and orally active inhibitor of 11β-HSD1, with low nanomolar IC50 values for human, rat, and mouse enzymes and high selectivity over 11β-HSD2. It functions as a competitive inhibitor and has been studied in research models for its potential to ameliorate insulin resistance and non-obese type 2 diabetes by targeting adipose and hepatic tissues.

Research Area

Metabolism Research

Key Properties

• CAS Number: 916828-66-5
• MW: 530.58
• Formula: C₂₈H₃₃F₃N₄O₃
• SMILES: C(=O)(C1=C(N(N=C1)C2CCN(C(=O)C3(CO)CC3)CC2)C4CC4)N5C[C@@H](CC5)C6=C(C(F)(F)F)C=CC=C6
• Target: Dehydrogenase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

15947669