HOIPIN-1

SKU: orb1298498

Description

JTP-0819958 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor exhibiting an IC50 of 2.8 μM. It effectively suppresses LUBAC-mediated NF-κB activation in vitro and serves as a valuable research tool for studying inflammatory signaling and immune responses in cellular models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2470242-33-0
• MW: 304.27
• Purity: 99.95% (May vary between batches)
• Formula: C₁₇H₁₃NaO₄
• SMILES: O=C(C1=C(C=CC(C2=C(OC)C=CC=C2)=O)C=CC=C1)[O-].[Na+]
• Target: IκB/IKK
• Solubility: DMSO:3.05 mg/mL (10.02 mM)

Bioactivity

• In Vitro:
  JTP-0819958 inhibited the linear polyubiquitination activity by the HOIL-1L/HOIP complex, the HOIL-1L/HOIP/SHARPIN complex, and the HOIP/SHARPIN complex equally, with IC50 values of 4.4, 3.5, and 3.7μM. The inhibitory effects of JTP-0819958 on LUBAC-mediated linear ubiquitin generation and inflammatory cytokine-induced NF-κB activation were confirmed in cellular levels.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

JTP 0819958 HOIPIN 1, JTP 0819958 HOIPIN1, JTP 0819958 - HOIPIN-1, IκB, IkB, IkB/IKK, IKK

Compound Identifiers

PubChem CID

137628274