JT002

• Catalog Number: orb2278379
• Category: Small Molecules
• Description: JT002 is an orally active NLRP3 inflammasome inhibitor that decreases the production of NLRP3-dependent proinflammatory cytokines (such as IL-1β, IL-1α, IL-18) and pyroptosis, as well as inhibits the formation of the NLRP3 inflammasome complex. Additionally, JT002 mitigates airway hyperresponsiveness and airway neutrophilia in mice.
• Target: NOD-like Receptor (NLR)
• MW: 432.49
• CAS Number: 2238820-43-2
• Formula: C₂₀H₂₄N₄O₅S
• SMILES: N(C(NS(=O)(=O)C1=C2N(N=C1)C[C@H](OC)CO2)=O)C3=C4C(=CC5=C3CCC5)CCC4
• Storage: -20°C
• Research Area: Immunology & Inflammation
• Note: For research use only