JR4-187

SKU: orb3210592

Description

JR4-187 is an orally active copper-dependent anti-cancer agent. It downregulates genes involved in oxidative phosphorylation, MYC targets, and E2F targets, while upregulating genes associated with the TNF-α signaling pathway, p53 pathway, and KRAS signaling pathway, in addition to reducing CTR1 protein levels. JR4-187 induces ROS production, apoptosis (apoptosis), and copper-dependent cytotoxicity, with selective cytotoxicity towards KRAS mutant cancer cells. It exhibits good tolerability in pancreatic cancer mouse models. JR4-187 is applicable for research in pancreatic ductal adenocarcinoma, colon cancer, rectal cancer, and other related cancers.

Key Properties

• CAS Number: 2446965-01-9
• MW: 436.48
• Formula: C₂₃H₂₅FN₆O₂
• SMILES: N[C@H]1C2(CCN(CC2)C=3C=NC(C(NC=4C5=C(C=C(F)C4)C=CC=N5)=O)=CN3)CO[C@H]1C
• Target: MDM-2/p53,Apoptosis,Early 2 Factor (E2F),TNF,ROS,c-Myc

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MDM-2/p53,Apoptosis,Early 2 Factor (E2F),TNF,ROS,c-Myc