(+)-JQ1 PA

SKU: orb1307588

Description

(+)-JQ1 PA is a potent BET bromodomain inhibitor derived from JQ1, exhibiting an IC50 of 10.4 nM. This cell-permeable probe is widely used in vitro and in vivo to investigate epigenetic regulation in oncology, immunology, and inflammation research.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2115701-93-2
• MW: 437.95
• Purity: 99.80% (May vary between batches)
• Formula: C₂₂H₂₀ClN₅OS
• SMILES: CC=1C2=C(N3C([C@H](CC(NCC#C)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C)SC1C
• Target: Epigenetic Reader Domain
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.57 mM);Ethanol:50 mg/mL (114.17 mM)

Bioactivity

• Target IC50:
  BET:10.4 nM
• In Vitro:
  The IC50 of (+)-JQ1 PA for BET is 10.4 nM, and the IC50 of JQ1 is 14.3 nM in MV4;11 cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

JQ1 PA, inhibit, EpigeneticReaderDomain, Epigenetic Reader Domain, Inhibitor, BET, (+)JQ1 PA, (+)-JQ1 PA, (+)-JQ-1 PA, (+) JQ1 PA

Compound Identifiers

PubChem CID

134821687