JQ-1 (carboxylic acid)

SKU: orb1301787

Description

JQ-1 (carboxylic acid) is a potent, cell-permeable small molecule inhibitor of BRD4, exhibiting IC50 values of 77 nM and 33 nM for its first and second bromodomains, respectively. This compound is widely used in vitro and in vivo to study epigenetic regulation, cancer biology, and inflammation by blocking BET protein function.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation

Key Properties

• CAS Number: 202592-23-2
• MW: 400.88
• Purity: 99.90% (May vary between batches)
• Formula: C₁₉H₁₇ClN₄O₂S
• SMILES: CC=1C2=C(N3C([C@H](CC(O)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C)SC1C
• Target: PD-1/PD-L1,Epigenetic Reader Domain
• Solubility: DMSO:125 mg/mL (311.81 mM);Ethanol:12.5 mg/mL (31.18 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.98 mM)

Bioactivity

• Target IC50:
  BRD4(1):77 nM |BRD4(2):33 nM
• In Vitro:
  JQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins, blocking their interaction with acetylated histones,it has been used as a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

polypeptide, remodeling, Epigenetic Reader Domain, EpigeneticReaderDomain, Inhibitor, inhibit, JQ 1, JQ 1 (carboxylic acid), JQ1, JQ-1, JQ1 (carboxylic acid), JQ-1 (carboxylic acid), JQ-1 carboxylic acid, bromodomain, carboxylic acid, chromatin, BRD4

Compound Identifiers

PubChem CID

66828107