JQ-1 carboxylic acid

SKU: orb1225742

Description

JQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins with Kd of 128, 59.5, 49.0, and 190 nM for JQ1 binding to bromodomains of BRD2, BRD3, BRD4, and BRDT, respectively, blocking their interaction with acetylated histones; a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.

Key Properties

• CAS Number: 202592-23-2
• MW: 400.8819
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₇ClN₄O₂S
• SMILES: O=C(O)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1
• Target: Bromodomain
• Solubility: DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

+)-JQ-1 carboxylic acid

Quick Database Links

Gene Symbol

Bromodomain