JPS036

SKU: orb1982924

Description

JPS036 is a VHL-based PROTAC that selectively degrades class I HDACs, primarily HDAC1/2. This degradation induces widespread gene expression changes and promotes apoptosis in cellular models like HCT116, supporting its use in oncology and epigenetics research.

Research Area

Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2669785-85-5
• MW: 940.18
• Formula: C₅₁H₆₆FN₇O₇S
• SMILES: Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)c(OCCCCCCCCCCCC(=O)Nc2ccc(cc2)C(=O)Nc2ccccc2N)c1
• Target: Others,HDAC,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

156808378